Which Formula Should I Use?
QTc is most reliable when the ECG is recorded near a heart rate of 60 beats per minute. Depending on the setting and on borderline results, repeating the ECG may be worthwhile.
This page cannot make a definitive choice for you. I personally would use Fridericia's formula.
- Vandenberk et al., 2016 compared several correction formulas in more than 6,600 adult, mostly European subjects. Fridericia and Sagie/Framingham performed better than Bazett.
- Bazett often overestimates QTc at higher heart rates. This can lead to false long-QT diagnoses and unnecessary treatment changes.
- The Framingham formula is based on a very large sample size and is often close to Fridericia at heart rates between 60 and 100.
- In research settings, formulas that take age and sex into account, such as Rautaharju, may be useful.
- Bazett is the most widely used formula for historical reasons and is used by many ECG machines.
Measurement Methods
The common methods for measuring the QT interval on an ECG are the threshold and tangent methods. The tangent method generally provides more accurate results. Automated systems sometimes tend to estimate QTc too high.
Thresholds for Long-/Short-QT Syndrome
Thresholds remain controversial. According to the ESC Guidelines 2022:
- Long-QT syndrome: from 480 ms, even if asymptomatic; from 460 ms if symptomatic.
- Short-QT syndrome: up to 320 ms, even if asymptomatic; up to 360 ms with symptoms or additional factors.
QTc Distribution in the Population
The chart in the calculator is based on Vandenberk et al., 2016 and assumes a normal distribution for QTc by Fridericia with a mean of 414 ms and a standard deviation of 25 ms.
Formulas
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